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Skipping titration steps or increasing doses too quickly can lead to severe nausea and vomiting, which might make continuing treatment difficult
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Consistent with the transcriptomic prediction, the GLP-1R agonist (GLP-1RA) exendin-4 (0.1,1, and 2 μg/kg body weight) reduced food intake in both WT and Bbs5 –/– fasted mice (Figure 4, K and L) in a dose-dependent manner (Figure 4, M and N)
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