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Drucker commented: “GLP‑1 [drugs] have given us so many wonderful results, but tackling these very challenging brain disorders has been disappointing… There was a hope that we would see some benefit, and we didn’t.” From the Alzheimer’s Drug Discovery Foundation (ADDF), Howard Fillit, MD, emphasized that “even negative trials move the field forward,” pointing to the need to target the broader pathobiology of Alzheimer’s and to consider preventive or combination approaches informed by biomarker profiles