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Well-documented data The B vitamins — thiamine, B12, B6, niacin, and riboflavin — are generally well tolerated at standard doses, though niacin can cause flushing and gastrointestinal upset, and high-dose vitamin B6 (above 1,000 mg daily) may cause nerve damage over time
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Death due to any cause was reduced by 20% [HR 0.80 (0.67–0.95)
