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Anti-emetic medications have important restrictions: Metoclopramide should only be used for a maximum of 5 days due to neurological side effect risks Domperidone should only be used short-term at the lowest effective dose, and is contraindicated in people with certain heart conditions or taking medications that affect heart rhythm All anti-emetics have potential side effects and drug interactions that your doctor will consider If severe vomiting or dehydration occurs, seek medical review