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Cell Survival and Proliferation: GLP-1 signaling activates the PI3K/Akt pathway, which promotes β-cell survival by inhibiting apoptotic signals (such as caspase activation) and enhancing proliferation (Zheng et al., 2024)
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In combination with insulin (with or without metformin), JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)
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