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The SURMOUNT-1 post-hoc analysis (n=2,542 women), published in Obesity journal 2025, found perimenopausal women on tirzepatide lost 23% of body weight vs 3% on placebo
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A recent study by Wang et al., which administered semaglutide only in the pre-pregnancy period to obese rats, reported that pre-pregnancy administration was sufficient to correct some of the changes to hypothalamic gene expression in fetal offspring [25], presumably via an improvement in maternal metabolic health
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