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In this context, prevention and early treatment of this vicious cycle is essential to reduce the risk of complications.16 Importance of albuminuria in CKD patients CKD is categorized according to eGFR (G1-G5) and albuminuria (A1-A3).5 Therefore, albuminuria is an essential element for the diagnosis of CKD, and prognostic, allowing clinicians to categorize CKD into various cardiovascular risk groups.11,12,17 Albuminuria, in addition to being a non-invasive and highly cost-effective diagnostic method for cardiovascular risk assessment,18 is an independent risk factor for cardiovascular morbidity and mortality.6,7,13 In fact, both eGFR and albuminuria are independent predictors of cardiovascular and renal events, as well as of increased mortality, multiplying the risk when both are deranged concurrently.5,14 Thus, for example, in the ADVANCE study, where 10,640 patients with T2DM were followed for an average of 4.3 years, it was found that, as uACR increased or eGFR decreased, the risk of cardiovascular events increased

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[DOI] [PubMed] [Google Scholar] 38.Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH