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Results from a blood-oxygen dependent functional MRI study [44] also suggest that mesolimbic reward-related areas may also mediate the anorectic effects of Ex in humans, with a hypothesised mechanism of decreasing responsiveness to contextual food cues (incentive salience, ‘wanting’) and increasing activity that correlates with consummatory reward value (‘liking’) [45]

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ICER gave semaglutide and tirzepatide their highest value rating for obesity vs diet alone