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TRPV1 has been shown to be expressed in the brain, β-cells (371), nociceptor C fibers, dorsal root ganglia, hepatocytes, spermatozoa (372), airway neurons (373), bladder and urothelium (374), blood vessels, and the whole gastrointestinal myenteric plexus (375), especially in colonic and rectal neurons (376)
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In the extracellular half of GLP-2R, accompanying the unwinding of the last two turns of TM6, TM7 moves outward and bends toward TM6 via a conserved pivot point G429 7.50b , which expands the TMD-binding pocket to accommodate peptide entrance and connection
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