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Mechanistically, it supports ATP synthesis, may improve glycemic control (via AMPK activation and GLUT-4 translocation), and has anti-inflammatory properties.🟢 The solution: Integrating creatine (3–5 g/day) with resistance training and adequate protein intake may help preserve lean mass and metabolic health during pharmacologically induced weight loss.🟢 The call to action: The authors strongly encourage researchers to investigate the effects of creatine in patients taking incretin-based therapies through rigorous, double-blind, placebo-controlled trials.🟢 The bottom line: Creatine is an affordable, safe, and well-tolerated adjunct that could help ensure weight loss is fat loss (not muscle loss) during treatment with GLP-1 receptor agonists and dual agonists.📚 Reference Ribeiro et al.(2026)

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In fact, a look at THNR relative to the largest U.S