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Quantitative PCR analysis Primers sequences were as follows: Irs1-Forward: 5’-TGGACATCACAGCAGAATGAAGA-3’ Irs1-Reverse: 5’-GACGTGAGGTCCTGGTTGTG-3’ Irs2-Forward: 5’-CACAGTCGTGAAAGAGTGAAGC-3’ Irs2-Reverse: 5’-GTTGGTCGGAAACATGCCAA-3’ Glp1r-Forward: 5’-TGTTGGCTTCAGACACTTGC-3’ Glp1r-Reverse: 5’-TACATCCACTTGAGGGCAGC-3’ Insr-Forward: 5’-ATGGGCTTCGGGAGAGGAT-3’ Insr-Reverse: 5’-GGATGTCCATACCAGGGCAC-3’ Cckar-Forward: 5’-AAAAGAATGGCAGTCTGCAGTG-3’ Cckar-Reverse: 5’-TGATAACCAGCGTGTTCCCC-3’ SUPPLEMENTARY FIGURES AND FIGURE LEGENDS ACKNOWLEDGMENTS The authors thank Dr

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