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Treatment discontinuations due to adverse effects were higher in the 10 mg and 15 mg tirzepatide groups compared to the 5 mg group and insulin glargine

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There’s also this recent headline: Which is a touchy subject and I don’t want to settle the European regulators investigation (notoriously not overly sensitive about things), but I’d venture to say that the psychological impact of obesity and the psychiatric side effects associated with changing body type including dysmorphia and eating disorders probably indicate that this is not a side effect of the drug but rather a side effect of the primary effect of the drug, in a small subset of patients