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On the other hand, disrupted insulin signaling mitigates hypothalamic kisspeptin expression, perturbing the hypothalamic–pituitary–gonadal (HPG) axis via altered mammalian target of rapamycin (mTOR)–kisspeptin pathway activity and impaired gonadotropin-releasing hormone (GnRH) secretion [65,66]

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However, their exact effects remain unclear

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