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Random effects network meta-analyses were estimated by the restricted maximum likelihood method and were used to account for heterogeneity between studies and calculate the pooled estimates and 95% confidence interval.37 We assessed heterogeneity with τ 2 (low 0.36) according to previously published methods.383940 The τ 2 was assumed the same for all contrasts in the network meta-analysis, and the correlation was assumed 0.5 in the between-study covariance matrix