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After activation by GIP, the endogenous transcription factor HEK293 binds to the response elements, inducing transcription of the luciferase reporter

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Drugs ORAL HYPOGLYCEMICS: : glyburide, glipizide, glimepiride Sulfonylureas : repaglinide, nateglinide Glinides : metformin Biguanide : acarbose, miglitol α-Glucosidase Inhibitors Thiazolidinediones or : pioglitazone, rosiglitazone Glitazones 1) : bromocriptine Dopamine agonist : canagliflozin, dapagliflozin, empagliflozin SGLT-2 Inhibitors : sitagliptin, saxagliptin, linagliptin, alogliptin DPP-IV Inhibitors INJECTIBLE HYPOGLYCEMICS : : exenatide, lixisenatide, liraglutide, albiglutide, dulaglutide, semaglutide GLP-1 Agonists : pramlintide Amylin Analog BILE ACID SEQUESTRANTS: colesevelam INSULINS: PRANDIAL: : lispro, aspart, glulisine, inhaled Rapid acting : regular crystalline zinc Short-acting BASAL: : NPH (or Isophane) Intermediate acting : glargine, detemir Long acting : degludec Ultra-long acting INSULIN + GLP1 COMBINATIONS: glargine + lixisenatide (Soliqua ®) degludec + liraglutide (Xultophy ®) GOALS OF THERAPY Figure X