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Representative immunohistochemical staining of TNF-α, Caspase-1, NLRP3, fibronectin, collagen I, and α-SMA in renal tissue of mice in each group was performed
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In summary, mitochondrial dysfunction and bioenergetic failure drive lipid accumulation and lipotoxicity in renal cells by impairing fatty acid oxidation and promoting oxidative stress, thereby accelerating DKD progression (Hou et al., 2024