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Compounds 47 and 48 (Figure 6), with IC 50 values of 0.83 and 0.43 μM, respectively, which possess aryl-substituted piperazines with acetamide linkers, showed the best activity as DPP-4 inhibitors
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[DOI] [PubMed] [Google Scholar] 26.Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N
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