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doi: 10.1210/jc.2007-1245

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Dietary considerations may play a supportive role, although these are not proven to prevent gallstones in GLP-1 users: Maintain regular meal patterns rather than severely restricting calories, which helps stimulate regular gallbladder contraction Include moderate amounts of healthy fats in the diet (such as olive oil, nuts, and oily fish) to promote gallbladder emptying Ensure adequate hydration to support bile flow Avoid very low-calorie diets unless under specialist supervision For individuals at particularly high risk—such as those with a history of gallstones, rapid weight loss, or multiple risk factors—some specialists may consider ursodeoxycholic acid (UDCA) prophylaxis