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קולטנים של GLP-1 ב-CNS, מפקחים על הרגישות לאינסולין בבעלי חיים, והשפעול של קולטנים אלה בעצבים היקפיים או בכלי-דם, עשוי להגביר שפיעת דם ברקמות, ולווסת באופן בלתי ישיר פעילות אינסולין
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As patients lose weight, blood pressure often naturally decreases, creating a paradoxical benefit: while semaglutide itself may cause mild blood pressure elevation in some individuals during early weeks, the subsequent weight loss typically produces a net reduction in systolic and diastolic readings
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