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No phase III randomized controlled trial has been conducted with perimenopausal or postmenopausal women as the primary population for any GLP-1 receptor agonist, as confirmed by multiple 2023-2024 narrative reviews
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The resultant opening of voltage-dependent L-type Ca 2+ channels increases the intracellular concentration of Ca 2+ , which also acts as a second messenger, augmenting neurotransmitter release [33]
